Volume 7.38 | Oct 1

Cord Blood News 7.38 October 1, 2015
Cord Blood News
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Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts
Investigators showed that transient expression of Tfap2c, Gata3, Eomes, and Ets2 is sufficient to reprogram mouse embryonic fibroblasts and post-natal tail-tip-derived fibroblasts into induced trophoblast stem cells and surmount the epigenetic barrier separating somatic from extra-embryonic lineages. [Cell Stem Cell]
Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-Like Cells
Researchers showed that transient expression of Gata3, Eomes, and Tfap2c in mouse fibroblasts induces stable, transgene-independent trophoblast stem-like cells. [Cell Stem Cell] Abstract | Graphical Abstract

Direct Comparison of Wharton Jelly and Bone Marrow Derived Mesenchymal Stromal Cells to Enhance Engraftment of Cord Blood CD34+ Transplants
Investigators evaluated the ability of Wharton’s jelly mesenchymal stromal cells (WJ MSC) to enhance hematopoietic stem and progenitor cells engraftment. They compared cultured human WJ MSC with human bone marrow-derived MSC for in vitro marker expression, immunomodulatory capacity and differentiation into three mesenchymal lineages. [Stem Cells Dev] Abstract

Umbilical Cord Blood Transplantation Outcomes in Acute Myelogenous Leukemia/Myelodysplastic Syndromes Patients ≥70 Years Old
Researchers retrospectively investigated the outcomes of umbilical cord blood transplantation after a reduced intensity conditioning regimen in patients with myelodysplastic syndrome and acute myelogenous leukemia ≥ 70 years. [Biol Blood Marrow Transplant] Abstract

Umbilical Cord Blood-Derived CD11c+ Dendritic Cells Could Serve as an Alternative Allogeneic Source of Dendritic Cells for Cancer Immunotherapy
Scientists compared CD11c+ umbilical cord blood-dendritic cells (DCs)/cytotoxic T lymphocytes (CTLs) with monocyte DCs/CTLs, using various parameters. [Stem Cell Res Ther] Full Article

Preterm Cord Blood Contains a Higher Proportion of Immature Hematopoietic Progenitors Compared to Term Samples
Researchers studied the functional properties of the umbilical cord blood progenitor cells collected from term and preterm neonates to establish whether quantitative and/or qualitative differences exist between the two groups. [PLoS One] Full Article

Bio-Distribution of Infused Human Umbilical Cord Blood Cells in Alzheimer’s Disease-Like Murine Model
Researchers followed the bioavailability of human umbilical cord blood cells in Alzheimer’s disease-like transgenic PSAPP mice and non-transgenic Sprague-Dawley rats. [Cell Transplant] Abstract

Mesenchymal Stem Cells of Different Origin: Comparative Evaluation of Proliferative Capacity, Telomere Length and Pluripotency Marker Expression
The authors characterized and compared proliferation, differentiation, telomere length and pluripotency marker expression in mesenchymal stem cells of various origins. [Life Sci] Abstract

Adenoviral Vector Carrying Glial Cell-Derived Neurotrophic Factor for Direct Gene Therapy in Comparison with Human Umbilical Cord Blood Cell-Mediated Therapy of Spinal Cord Injury in Rat
Scientists evaluated the treatment of spinal cord injury with glial cell-derived neurotrophic factor delivered using an adenoviral vector in comparison with treatment performed using human umbilical cord blood mononuclear cells-transduced with an adenoviral vector carrying the GDNF gene in rat. [Spinal Cord] Abstract

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Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells
The authors present emerging strategies based on ex vivo manipulation of graft hematopoietic stem cells (HSCs) that are aimed at enhancing the responsiveness of HSCs to bone marrow (BM)-secreted chemoattractants and/or promoting HSC adhesion and seeding efficiency in the BM microenvironment. [Stem Cell Rev] Full Article

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New York Blood Center Announces New Collaboration to Foster Groundbreaking Advancements in Regenerative Medicine
New York Blood Center and the Howard and Abby Milstein Foundation announced a further expansion of their collaborative efforts to advance the use of specialized stem cell lines in regenerative medicine. [New York Blood Center] Press Release

Global Stem Cells Group, Inc. Announces Collaboration with VidaCel Laboratories and Stem Cell Bank, Chile
Global Stem Cells Group has announced a new collaboration with Santiago, Chile-based VidaCell Laboratories, Latin America’s oldest and largest cryopreserved umbilical cord cell bank. The alliance is focused on creating new protocols for cryopreservation of cord blood, cord tissue, adipose tissue and dental pulp stem cells, and the culture and expansion of cell colonies. [Global Stem Cells Group, Inc. (PRWeb)] Press Release

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Therapeutic Goods Administration (Australia)
NEW Cancer as an Evolving and Systemic Disease
March 12-15, 2016
New York City, United States

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NEW Postdoctoral Positions – Cancer and Developmental Biology (North Carolina Central University)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Senior Stem Cell Scientist (Wellcome Trust Sanger Institute)

Postdoctoral Fellow – Computational Biology/Bioinformatics (Princess Margaret Cancer Center)

Postdoctoral Researcher – Epigenetic Modifiers (Van Andel Research Institute)

Director of Research – Oncology and Hematology (CancerCare Manitoba)

Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Assays (Weill Cornell Medical School)

Postdoctoral Fellow – Hematopoietic Regeneration and Myeloid Malignancies (Weill-Cornell Medical College)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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