Volume 7.46 | Nov 26

Cord Blood News 7.46 November 26, 2015
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Umbilical Cells Help Eye’s Neurons Connect
Cells isolated from human umbilical cord tissue have been shown to produce molecules that help retinal neurons from the eyes of rats grow, connect and survive. [Press release from Duke University discussing online prepublication in The Journal of Neuroscience] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
RNA-Based, Transient Modulation of Gene Expression in Human Hematopoietic Stem and Progenitor Cells
Researchers aimed at exploring new ways to transiently modify hematopoietic stem and progenitor cell gene expression using non-integrating, RNA-based molecules. [Sci Rep] Full Article

Efficient Gene Delivery to Human Umbilical Cord Mesenchymal Stem Cells by Cationized Porphyra yezoensis Polysaccharide Nanoparticles
This study centered on an innovative application of Porphyra yezoensis polysaccharide with cationic modification as a safe and efficient nonviral gene vector to deliver a plasmid encoding human Wnt3a into human umbilical cord mesenchymal stem cells. [Int J Nanomedicine] Abstract

Immunomodulation of Endothelial Differentiated Mesenchymal Stromal Cells: Impact on T and NK Cells
The authors determined the impact of differentiation toward endothelial cells on immunoregulation by Wharton’s jelly mesenchymal stromal cells. [Immunol Cell Biol] Abstract

Secretome Profiling of Cytokines and Growth Factors Reveals that Neuro-Glial Differentiation Is Associated with the Down-Regulation of Chemokine Ligand 2 (MCP-1/CCL2) in Amniotic Fluid Derived-Mesenchymal Progenitor Cells
Researchers used the newly characterized human amniotic fluid derived-mesenchymal progenitor MePR-2B cell line differentiated to a neuro-glial phenotype and exploited the very high sensitivity and versatility of magnetic beads-based immunoassays. [Proteomics] Abstract

The Effect of Fibroblast Growth Factor on Distinct Differentiation Potential of Cord Blood-Derived Unrestricted Somatic Stem Cells and Wharton’s Jelly-Derived Mesenchymal Stem/Stromal Cells
Investigators compared the basic characteristics of unrestricted somatic stem cells isolated from cord blood and mesenchymal stem/stromal cells isolated from Wharton’s jelly of umbilical cords. They also evaluated the effect of basic fibroblast growth factor supplementation on the growth and differentiation of these cells. [Cytotherapy] Abstract

Cord Blood Banking and Quality Issues
Scientists applied the cell therapy quality system to all cord blood units shipped into the cellular therapy laboratory for transplant between 2011 and 2013. The quality issues were categorized as likely, potentially, or unlikely to have a clinical impact. [Transfusion] Abstract

Mesenchymal Stem Cell Conditioned Medium Promotes Proliferation and Migration of Alveolar Epithelial Cells under Septic Conditions In Vitro via the JNK-P38 Signaling Pathway
Researchers investigated the impact of human umbilical cord Wharton’s jelly-derived mesenchymal stem cell secreted factors on alveolar epithelial cells under septic conditions and determined the relevant intracellular signaling pathways. [Cell Physiol Biochem] Full Article

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REVIEWS
Allogeneic Transplantation for CML in the TKI Era: Striking the Right Balance
The majority of chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs) achieve excellent responses with sustained treatment; however, for an almost equal number of patients, an adequate response cannot be achieved with any of the currently available TKIs. For those patients who fail to respond adequately to TKIs, hematopoietic stem-cell transplantation offers the best prospect of long-term survival. [Nat Rev Clin Oncol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

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INDUSTRY NEWS
European Commission Approves Amgen’s BLINCYTO® (Blinatumomab) for the Treatment of Adults with Philadelphia Chromosome-Negative Relapsed or Refractory B-Precursor Acute Lymphoblastic Leukemia
Amgen announced that the European Commission has granted conditional marketing authorization for BLINCYTO® for the treatment of adults with Philadelphia chromosome-negative relapsed or refractory B-precursor acute lymphoblastic leukemia. [Amgen Inc.] Press Release

MD Anderson Receives $22.2 Million in CPRIT Research Funding
The University of Texas MD Anderson Cancer Center was awarded more than $22 million in research grants from the Cancer Prevention and Research Institute of Texas (CPRIT). MD Anderson CPRIT awards included $14.8 million for research, $6 million in recruitment funding and $1.4 million for evidence-based cancer prevention services. [The University of Texas MD Anderson Cancer Center] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 16th International Congress of Immunology
August 21-26, 2016
Melbourne, Australia

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Assistant Member – Cord Blood Transplantation (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Scientist – Immunotherapy Group (The Anthony Nolan Trust)

Faculty Positions – Regenerative Medicine for Organ Regeneration or Transplantation (The University of Texas Medical School at Houston)

Postdoctoral Fellow – Leukemia Research (City of Hope)

Faculty Member – Hematopoietic Cell Transplant (Fred Hutchinson Cancer Research Center)

Hematopoietic Stem Cell Biologist (Mayo Clinic)

Assistant or Associate Professor – Cell and Regenerative Biology (University of Wisconsin, Madison)

Assistant Member – Cord Blood Transplantation (Fred Hutchinson Cancer Research Center)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)


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