Volume 8.00 | Jan 7

Cord Blood News 8.00 January 7, 2016
Cord Blood News
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Xenograft of Human Umbilical Mesenchymal Stem Cells from Wharton’s Jelly as a Potential Therapy for Rat Pilocarpine-Induced Epilepsy
Scientists evaluated the effects of intra-hippocampal transplantation of human umbilical mesenchymal stem cells (HUMSCs) on pilocarpine-treated rats. They demonstrated the therapeutic benefits of HUMSC transplantation for the development of epilepsy. [Brain Behav Immun] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
The Therapeutic Potential of Human Umbilical Mesenchymal Stem Cells from Wharton’s Jelly in the Treatment of Rat Peritoneal Dialysis-Induced Fibrosis
The authors demonstrated that direct intraperitoneal transplantation of human umbilical mesenchymal stem cells into rats effectively prevented peritoneal dialysis/methylglyoxal-induced abdominal cocoon formation, ultrafiltration failure, and peritoneal membrane alterations such as peritoneal thickening, fibrosis, and inflammation. [Stem Cells Transl Med] Abstract

Potency of Umbilical Cord Blood- and Wharton’s Jelly-Derived Mesenchymal Stem Cells for Scarless Wound Healing
Umbilical cord blood (UCB)-MSCs expressed lower levels of the pre-inflammatory cytokines IL1A and IL1B, but higher levels of the extracellular matrix-degradation enzymes MMP1 and PLAU compared with Wharton’s jelly-MSCs, suggesting that UCB-MSCs were more likely to favor scarless wound healing. [Sci Rep] Full Article

Discovery of Novel INK4C Small-Molecule Inhibitors to Promote Human and Murine Hematopoietic Stem Cell Ex Vivo Expansion
Researchers identified a lead p18 inhibitor, XIE18-6, confirmed its p18-targeting specificity and bioactivity of promoting hematopoietic stem cells expansion, and then performed structure-activity relationship (SAR) studies by synthesizing a series of analogs of XIE18-6. [Sci Rep] Full Article

Transplantation of Placenta-Derived Mesenchymal Stem Cells Reduces Hypoxic-Ischemic Brain Damage in Rats by Ameliorating the Inflammatory Response
Investigators explored the immunoregulatory mechanism of placenta-derived mesenchymal stem cells (PD-MSCs) in hypoxic-ischemic brain damage treatment. PD-MSC treatment inhibited the production of pro-inflammatory cytokines and increased the production of interleukin-10 in the ischemic hemispheres and peripheral blood serum. [Cell Mol Immunol] Abstract

MiR-26b-3p Regulates Human Umbilical Cord Derived Mesenchymal Stem Cell Proliferation by Targeting Estrogen Receptor Alpha
Researchers explored the roles of miRNAs in regulating the in vitro proliferation of human umbilical cord derived mesenchymal stromal cells (hUC-MSC). They found that miR-26b-3p was significantly up-regulated during serial in vitro passage of hUC-MSC and was correlated with cellular senescence and cell cycle genes. [Stem Cells Dev] Abstract

Human Umbilical Cord Mesenchymal Stem Cells Delivering sTRAIL Home to Lung Cancer Mediated by MCP-1/CCR2 Axis and Exhibit Antitumor Effects
The migration of human umbilical cord mesenchymal stem cells to lung cancer was observed through transwell migration assay and animal bioluminescent imaging both in vitro and in vivo. [Tumor Biol] Abstract

Chondrogenic Induction of Mesenchymal Stromal/Stem Cells from Wharton’s Jelly Embedded in Alginate Hydrogel and without Added Growth Factor: An Alternative Stem Cell Source for Cartilage Tissue Engineering
Investigators evaluated chondrogenic differentiation of Wharton’s jelly-mesenchymal stromal/stem cells (WJ-MSC) on three-dimensional scaffolds, without adding growth factors, at transcript and protein levels. Once seeded in the hydrogel scaffold, WJ-MSCs and bone marrow-MSCs have different profiles of chondrogenic differentiation at both the phenotypic level and matrix synthesis. [Stem Cell Res Ther] Full Article

Glial Cell Line-Derived Neurotrophic Factor Induced the Differentiation of Amniotic Fluid-derived Stem Cells into Vascular Endothelial-Like Cells In Vitro
Scientists investigated the effect of an adenovirus-mediated GDNF gene, which was engineered into amniotic fluid-derived stem cells (AFSCs), on the cells’ biological properties and whether GDNF in combination with AFSCs can be directionally differentiated into vascular endothelial-like cells in vitro. [J Mol Histol] Abstract

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Allogeneic Stem Cell Transplantation for Multiple Myeloma: Is There a Future?
The authors provide an in-depth review of literature for allogeneic hematopoietic cell transplantation and other immunotherapy [Bone Marrow Transplant] Abstract

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U.S. Food & Drug Administration Grants Orphan Drug Designation to Pluristem’s PLX-PAD Cells for Treatment of Severe Preeclampsia
Pluristem Therapeutics Inc. announced that the U.S. Food and Drug Administration has granted the company’s PLX-PAD cells orphan drug designation in the treatment of severe preeclampsia. [Pluristem Therapeutics Inc.] Press Release

Strategia Therapeutics Announces Progress in a Phase I Clinical Trial of the Anti-Cancer Agent “FF-10501-01” for FUJIFILM in Patients with Advanced Hematologic Malignancies
Strategia Therapeutics, Inc. announced progress in a Phase I clinical trial of FUJIFILM’s anti-cancer agent, FF-10501-01 in the United States in patients with relapsed or refractory myelodysplastic syndromes and acute myeloid leukemia. [Strategia Therapeutics, Inc.] Press Release

Creative Medical Health Granted U.S. Patent for Heart Failure Stem Cell Therapy
Creative Medical Health Inc. announced issuance of U.S. Patent #9,205,112, titled “Combination Therapy of Cardiovascular Disease” by the United States Patent and Trademark Office. The patent covers the use of adult stem cells such as cord blood and mesenchymal stem cells in combination with modulation of oxidative stress in treatment of heart failure [Creative Medical Health Inc. (BusinessWire)] Press Release

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European Medicines Agency (European Union)

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Therapeutic Goods Administration (Australia)
NEW ICCSCE 2016: 18th International Conference on Cell and Stem Cell Engineering
September 15-16, 2016
Rome, Italy

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NEW Postdoctoral Fellow – Stem Cell Biology (Krembil Research Institute)

NEW Research Specialist – Stem Cells from the Hematopoietic System (Howard Hughes Medical Institute)

NEW Doctoral Fellow – Stem Cell Research (Krembil Research Institute)

NEW Postdoctoral position – Regenerative Medicine (University of Copenhagen)

NEW Stem Cell Scientist and Postdoctoral Positions (National Center for Advancing Translational Science)

Postdoctoral Position – Cell and Molecular Biology of Leukemia (Virginia Commonwealth University)

Postdoctoral Research Scientist – Lymphocyte Trafficking Mechanisms in Allogeneic Stem-Cell Transplantation (Columbia University Medical Center)

Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Assistant Member – Cord Blood Transplantation (Fred Hutchinson Cancer Research Center)

Assistant Member – Cord Blood Transplantation (Fred Hutchinson Cancer Research Center)

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