Volume 8.02 | Jan 21

Cord Blood News 8.02 January 21, 2016
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Cord Blood Monocyte–Derived Inflammatory Cytokines Suppress IL-2 and Induce Nonclassic “TH2-Type” Immunity Associated with Development of Food Allergy
In a general population-derived birth cohort, scientists found that in infants who developed food allergy, cord blood displayed a higher monocyte to CD4+ T cell ratio and a lower proportion of natural regulatory T cell in relation to duration of labor. [Sci Transl Med] Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
Analysis of Non-Relapse Mortality and Causes of Death over 15 Years following Allogeneic Hematopoietic Stem Cell Transplantation
Investigators performed a retrospective single-center study to assess changes in outcomes after allogeneic hematopoietic stem cell transplantation and causes of non-relapse mortality over three five year periods. [Bone Marrow Transplant] Abstract

A Phase I Study of Reduced Intensity Conditioning and Allogeneic Stem Cell Transplantation followed by Dose Escalation of Targeted Consolidation Immunotherapy with Gemtuzumab Ozogamicin in Children and Adolescents with CD33+ Acute Myeloid Leukemia
Researchers examined the feasibility and toxicity of reduced-intensity conditioning-allogeneic hematopoietic stem cell transplant followed by gemtuzumab ozogamicin targeted immunotherapy in children with CD33+ acute myeloid leukemia in first complete remission/second complete remission. [Biol Blood Marrow Transplant] Abstract

Effects of Gestational Magnetic Resonance Imaging on Methylation Status of Leptin Promoter in the Placenta and Cord Blood
The authors investigated DNA methylation patterns of leptin promoter in the placenta and cord blood of women exposed to magnetic resonance imaging (MRI) during gestation. Results showed that average methylation levels of leptin in the placenta and cord blood were not affected by MRI. [PLoS One] Full Article

ESAM Is a Novel Human Hematopoietic Stem Cell Marker Associated with a Subset of Human Leukemias
Researchers found that endothelial cell-selective adhesion molecule (ESAM) can be used to purify human hematopoietic stem cells from all the currently available sources (adult bone marrow, mobilized peripheral blood, and cord blood). [Exp Hematol] Abstract

Clinical and Laboratory Outcomes after Umbilical Cord Blood Transplantation in a Patient with Mucolipidosis II Alpha/Beta
A 26-month-old girl received a human leukocyte antigen 3/6-allele-matched transplant from cord blood. Comparing before and after cord blood transplantation results, scientists observed that lysosomal enzyme activities in the plasma decreased by approximately 20-40%. [Am J Med Genet A] Abstract

Apelin: An Endogenous Peptide Essential for Cardiomyogenic Differentiation of Mesenchymal Stem Cells via Activating Extracellular Signal-Regulated Kinase 1/2 and 5
Researchers investigated the role of apelin in the cardiomyogenic differentiation of mesenchymal stem cells derived from Wharton’s jelly of human umbilical cord in vitro. [Cell Biol Int] Abstract

Post-Test Probability for Neonatal Hyperbilirubinemia Based on Umbilical Cord Blood Bilirubin, Direct Antiglobulin Test, and ABO Compatibility Results
The authors investigated the predictive value of umbilical cord blood (UCB) testing for significant hyperbilirubinemia. Neonatal UCB bilirubin, UCB direct antiglobulin test, and blood group were determined, as well as the maternal blood group and the red blood cell antibody status. [Eur J Pediatr] Abstract

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REVIEWS
Cord Blood Transplant for Acute Myeloid Leukemia
The authors review controversial issues, including the use of double versus single cord blood units for transplantation, optimal cord blood unit selection, infection prophylaxis, conditioning regimens and graft versus host disease prophylaxis. [Br J Haematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Perinatal Stem Cell Society 2016
 
INDUSTRY NEWS
AbbVie’s Venetoclax Receives Breakthrough Therapy Designation from FDA in Combination with Rituximab for the Treatment of Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia
AbbVie announced that the U.S. Food and Drug Administration (FDA) granted breakthrough therapy designation for venetoclax in combination with rituximab for the treatment of patients with relapsed/refractory chronic lymphocytic leukemia. [AbbVie] Press Release

$5 Million Donation from the Hospira Foundation Will Support Research in Cancer Care, Prevention and Treatment
The Hospira Foundation has donated $5 million to the University of Chicago Medicine to create the Hospira Foundation Professorship in Oncology. This position significantly bolsters the University’s capacity to conduct pioneering research in cancer. [The University of Chicago] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW European Society for Medical Oncology (ESMO) 2016
October 7-11, 2016
Copenhagen, Denmark

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Research Fellow/Research Officer – Zeb2 Transcription Factor in Hematopoietic Stem Cell Differentiation (Monash University)

PhD Position – Stem Cells and Transplantation (University of Geneva)

Postdoctoral Fellow – Stem Cell Biology (Krembil Research Institute)

Research Specialist – Stem Cells from the Hematopoietic System (Howard Hughes Medical Institute)

Doctoral Fellow – Stem Cell Research (Krembil Research Institute)

Postdoctoral position – Regenerative Medicine (University of Copenhagen)

Stem Cell Scientist and Postdoctoral Positions (National Center for Advancing Translational Science)

Postdoctoral Position – Cell and Molecular Biology of Leukemia (Virginia Commonwealth University)

Postdoctoral Research Scientist – Lymphocyte Trafficking Mechanisms in Allogeneic Stem-Cell Transplantation (Columbia University Medical Center)

Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Assistant Member – Cord Blood Transplantation (Fred Hutchinson Cancer Research Center)


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