Volume 8.05 | Feb 11

Cord Blood News 8.05 February 11, 2016
Cord Blood News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Cellular Ontogeny and Hierarchy Influence the Reprogramming Efficiency of Human B-Cells into Induced Pluripotent Stem Cells
Scientists addressed whether cell ontogeny and hierarchy influence the reprogramming efficiency of the B-cell compartment. They demonstrated that human fetal liver-derived CD19+ B-cells are 110-fold easier to reprogram into induced pluripotent stem cells than those from cord blood and peripheral blood. [Stem Cells] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Cord Blood Ferritin and Fibroblast Growth Factor-23 Levels in Neonates
C-terminal fibroblast growth factor-23 (FGF23), but not intact FGF23 levels, are elevated in cord blood of healthy term neonates and independently associated with lower serum ferritin and higher glycemic indices. [J Clin Endocrinol Metab] Abstract | Full Article

The Effect of Bisphosphonates on the Endothelial Differentiation of Mesenchymal Stem Cells
Scientists evaluated the effects of various bisphosphonates on the differentiation of human placental mesenchymal stem cells along the endothelial lineage and their subsequent functional and morphogenic capabilities. [Sci Rep] Full Article

Infusion of CD3/CD28 Co-Stimulated Umbilical Cord Blood T Cells at the Time of Single Umbilical Cord Blood Transplantation May Enhance Engraftment
Researchers tested whether ex vivo activation by CD3/CD28 costimulation and expansion of T cells from a single umbilical cord blood graft would be safe and feasible in adults with advanced hematologic malignancies, with an overall objective of optimizing engraftment in single unit umbilical cord blood transplantation. [Am J Hematol] Abstract

Endothelial Progenitor Cells Promote Efficient Ex Vivo Expansion of Cord Blood–Derived Hematopoietic Stem/Progenitor Cells
Investigators designed an ex vivo culture system using endothelial progenitor cells as stroma to determine the capacity of expanding cord blood-hematopoietic stem/progenitor cells in a defined medium, the effect on engraftment of the expanded cells in a mouse model and the underlying mechanism. [Cytotherapy] Abstract

The Effects of Culture Conditions on the Functionality of Efficiently Obtained Mesenchymal Stromal Cells from Human Cord Blood
Scientists demonstrated 87% efficacy in generating mesenchymal stromal cells (MSCs) from cord blood. The established cells had typical MSC characteristics with reduced adipogenic differentiation potential and a unique HOX gene fingerprint. [Cytotherapy] Abstract

A Chemically Defined Medium-Based Strategy to Efficiently Generate Clinically Relevant Cord Blood Mesenchymal Stromal Colonies
Researchers proposed a straightforward, extremely efficient, and reliable approach to isolate and expand thoroughly characterized cord blood (CB) mesenchymal stromal cells, even when poor-quality CB units are the only disposable source or there is no space for an isolation to fail. [Cell Transplant] Abstract

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REVIEWS
Therapeutically Targeting Self-Reinforcing Leukemic Niches in Acute Myeloid Leukemia (AML): A Worthy Endeavour?
A tight relationship between the AML population and the bone marrow (BM) microenvironment has been convincingly established. The AML clone contains leukemic stem cells that compete with normal hematopoietic stem cells for niche occupancy and remodel the niche; whereas, the BM microenvironment might promote AML development and progression not only through hypoxia and homing/adhesion molecules, but also through genetic defects. [Am J Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
 
INDUSTRY NEWS
With $3 Million Award, HSU Generates Stem Cell Scholars
Humboldt State University (HSU) biology professors Jacob Varkey and Amy Sprowles are among educators at 12 universities to secure funding from the California Institute for Regenerative Medicine’s Bridges 2.0 Training Program. The award of $3,044,950 will fund stem cell training for HSU students and support up to ten paid research internships annually for the next five years. [Humboldt State University] Press Release

NIH Awards $2.8 Million to FAU Researchers and Collaborators
The National Eye Institute of the National Institutes of Health (NIH) has awarded a $2.8 million, multi-institution grant to researchers at Florida Atlantic University (FAU) and Thomas Jefferson University. Researchers will work to define the mechanisms governing how cells decide whether to become a mature cell or whether to die. Their work will shed light on how to make transplantable tissues to cure diseases. [Florida Atlantic University] Press Release

Immune Pharmaceuticals Files New Patent Application for Ceplene in Combination with Checkpoint Inhibitors
Immune Pharmaceuticals Inc. announced that it has filed a patent application directed to the treatment of acute myeloid leukemia and other cancers. [Immune Pharmaceuticals Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW American Society of Gene & Cell Therapy (ASGCT) 19th Annual Meeting 2016
May 4-7, 2016
Washington, United States

Visit our events page to see a complete list of events in the cord blood community.
 
JOB OPPORTUNITIES
NEW Translational Research Scientist – Hematology/Oncology (University of Chicago)

NEW Postdoctoral Associate – Epigenetic Regulation of Normal and Leukemic Stem Cells (Sanford Burnham Prebys Medical Discovery Institute)

NEW Postdoctoral Positions – Immunology, Cancer, and Stem Cells (University of Connecticut)

Translational Research Scientist – Hematology/Oncology (University of Chicago)

PhD Position – Stem Cells and Transplantation (University of Geneva)

Doctoral Fellow – Stem Cell Research (Uniklinik Koln)

Postdoctoral position – Regenerative Medicine (University of Copenhagen)

Postdoctoral Position – Cell and Molecular Biology of Leukemia (Virginia Commonwealth University)

Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Assistant Member – Cord Blood Transplantation (Fred Hutchinson Cancer Research Center)


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