Therapeutically Targeting Self-Reinforcing Leukemic Niches in Acute Myeloid Leukemia (AML): A Worthy Endeavour?|
A tight relationship between the AML population and the bone marrow (BM) microenvironment has been convincingly established. The AML clone contains leukemic stem cells that compete with normal hematopoietic stem cells for niche occupancy and remodel the niche; whereas, the BM microenvironment might promote AML development and progression not only through hypoxia and homing/adhesion molecules, but also through genetic defects. [Am J Hematol] Abstract
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