Therapeutically Targeting Self-Reinforcing Leukemic Niches in Acute Myeloid Leukemia (AML): A Worthy Endeavour?
A tight relationship between the AML population and the bone marrow (BM) microenvironment has been convincingly established. The AML clone contains leukemic stem cells that compete with normal hematopoietic stem cells for niche occupancy and remodel the niche; whereas, the BM microenvironment might promote AML development and progression not only through hypoxia and homing/adhesion molecules, but also through genetic defects. [Am J Hematol] Abstract
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INDUSTRY NEWS
With $3 Million Award, HSU Generates Stem Cell Scholars
Humboldt State University (HSU) biology professors Jacob Varkey and Amy Sprowles are among educators at 12 universities to secure funding from the California Institute for Regenerative Medicine’s Bridges 2.0 Training Program. The award of $3,044,950 will fund stem cell training for HSU students and support up to ten paid research internships annually for the next five years. [Humboldt State University] Press Release
NIH Awards $2.8 Million to FAU Researchers and Collaborators
The National Eye Institute of the National Institutes of Health (NIH) has awarded a $2.8 million, multi-institution grant to researchers at Florida Atlantic University (FAU) and Thomas Jefferson University. Researchers will work to define the mechanisms governing how cells decide whether to become a mature cell or whether to die. Their work will shed light on how to make transplantable tissues to cure diseases. [Florida Atlantic University] Press Release
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