Volume 8.13 | Apr 7

Cord Blood News 8.13 April 7, 2016
Cord Blood News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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Massive Clonal Selection and Transiently Contributing Clones during Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology
Investigators used multicolor lentiviral barcode labeling to follow the clonal dynamics during in vitro mesenchymal stem (or stromal) cells expansion from whole umbilical cord pieces. [Stem Cells Transl Med] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Tissue-Specific Differentiation Potency of Mesenchymal Stromal Cells from Perinatal Tissues
Scientists successfully isolated and cultured mesenchymal stromal cells from amnion (AMSCs), chorion, and umbilical cord. Proliferation potential was different among them, that AMSCs revealed the lowest proliferation rate due to increased Annexin V and senescence-associated β-galactosidase positive cells. [Sci Rep] Full Article

Impact of Early CMV Reactivation in Cord Blood Stem Cell Recipients in the Current Era
The unique combination of higher incidence of CMV reactivation in the seropositive recipient and lower incidence of graft versus host disease in cord blood (CB) hematopoietic cell transplantation (HCT) permits a valuable design to analyze the impact of CMV reactivation. Data from 1684 patients transplanted with CB between 2003 and 2010 for AML and ALL were analyzed. [Bone Marrow Transplant] Abstract

Autologous Stem Cell Transplantation for Patients Aged 60 Years or Older with Refractory or Relapsed Classical Hodgkin’s Lymphoma: A Retrospective Analysis from the French Society of Bone Marrow Transplantation and Cell Therapies (SFGM-TC)
Researchers retrospectively analyzed the outcome of 91 patients aged 60 years or older with refractory/relapsed classical Hodgkin’s lymphoma who underwent autologous stem cell transplantation between 1992 and 2013 and were reported to the French Society of Bone Marrow Transplantation and Cell Therapies registry. [Bone Marrow Transplant] Abstract

Cytogenetics Does Not Impact the Outcome of Adult Patients with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation
Investigators retrospectively analyzed the outcome of 333 adult acute lymphoblastic leukemia patients who underwent allogeneic hematopoietic stem cell transplantation at their institution over a 10-year period. [Biol Blood Marrow Transplant] Abstract

VCAM-1+ Placenta Chorionic Villi-Derived Mesenchymal Stem Cells Display Potent Pro-Angiogenic Activity
Researchers assessed whether VCAM-1 can be used as a marker of mesenchymal stem cells subpopulation with superior angiogenic potential. [Stem Cell Res Ther] Full Article

DMSO- and Serum-Free Cryopreservation of Wharton’s Jelly Tissue Isolated from Human Umbilical Cord
Investigators compared the effect of two different cryoprotectants (dimethyl sulfoxide [DMSO] & cocktail solution) on post-thaw cell behavior upon freezing of Wharton’s jelly tissue following two different freezing protocols. [J Cell Biochem] Abstract

A Novel Molecular and Functional Stemness Signature Assessing Human Cord Blood-Derived Endothelial Progenitor Cell Immaturity
To better characterize cord blood-derived-endothelial colony forming cells stemness, scientists quantified their clonogenic potential and demonstrated that they were reprogrammed into induced pluripotent stem cells more efficiently and rapidly than adult endothelial cells. [PLoS One] Full Article

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The Placenta as an Organ and a Source of Stem Cells and Extracellular Matrix: A Review
Differences among several mammalian species regarding the placental types and classifications, phenotypes and potency of placenta-derived stem/progenitor cells, placental extracellular matrix (ECM) components and current placental ECM applications were reviewed to highlight their potential clinical and biomedical relevance. [Cells Tissues Organs] Full Article

Visit our reviews page to see a complete list of reviews in the cord blood research field.
Gamida Cell Presents Additional Positive Data of NiCord® in Blood Cancer Patients
Gamida Cell announced additional positive results with the use of NiCord®, an experimental treatment for patients with high-risk blood cancers. The data was presented in an oral session titled Transplantation of Ex vivo Expanded Umbilical Cord Blood Results in Decreased Infection Burden and Hospital Length of Stay in the First 100 Days. [Press release from Gamida Cell discussing research presented at the 42nd Annual Meeting of the European Society for Blood and Marrow Transplantation, Valencia] Press Release

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California Cryobank Stem Cell Services Acquires Southern Cord
California Cryobank Stem Cell Services LLC, announced the recent acquisition of Southern Cord Inc. Southern Cord clients will maintain full access to their invaluable stem cells, and all prepaid contracts will be honored. [California Cryobank Stem Cell Services LLC (PR Newswire Association LLC)] Press Release

CHOP Oncologist Receives $1 Million Hyundai Quantum Grant to Improve Leukemia Treatment
A physician-researcher at The Children’s Hospital of Philadelphia (CHOP) has received a $1 million Hyundai Quantum Grant from Hyundai Hope on Wheels to advance treatment for a high-risk form of childhood leukemia. The research focuses on immunotherapy—an approach that utilizes a patient’s immune system to better fight off cancer. [The Children’s Hospital of Philadelphia] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 14th International Cord Blood Symposium
June 9-11, 2016
San Francisco, United States

Visit our events page to see a complete list of events in the cord blood community.
NEW Principal Investigator – Stem Cell Biology and Regeneration Medicine (Guangzhou Women and Children’s Medical Center)

NEW Engineering Project Lead (Cytonome)

Postdoctoral Scientist – Hematological Malignancies (Max Delbruck Center for Molecular Medicine in the Helmholtz Association)

Postdoctoral Research Associate – Pediatric Acute Lymphoblastic Leukemia (University of Pittsburgh)

Postdoctoral Research Associate – Blood Stem cell Microenvironment (University of Illinois)

Associate Scientist – Hematopoietic Stem Cell Biology (Editas Medicine)

Research Associate – Hematopoietic Stem Cell Biology (Editas Medicine)

Postdoctoral Fellow – Hematology/Oncology (Boston Children’s Hospital)

Research Fellow – Erythropoiesis (New York Blood Center)

Postdoctoral Fellow – Stem Cell Biology and Regenerative Medicine (Cleveland Clinic)

Postdoctoral Positions – Immunology, Cancer, and Stem Cells (University of Connecticut)

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