Volume 8.16 | Apr 28

Cord Blood News 8.16 April 28, 2016
Cord Blood News
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Researchers Find New Way to Grow Life-Saving Blood Stem Cells
Researchers have discovered how a key protein allows for better control and regeneration of blood stem cells. This discovery illustrates how a protein called Musashi-2 regulates the function and development of important blood stem cells. The research team specifically looked at stem cells from umbilical cord blood, a proven but under-utilized source of stem cells for the treatment of adult blood cancers. [Press release from McMaster University discussing online prepublication in Nature] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Both High and Low Levels of Cellular Epstein-Barr Virus DNA in Blood Identify Failure after Hematologic Stem Cell Transplantation in Conjunction with Acute GVHD and Type of Conditioning
The authors evaluated the impact of EBV load on survival of 51 patients, who had received hematopoietic stem cell transplantation patients for different types of malignancies or non-malignancies. Different sources of stem-cells (peripheral blood stem, bone marrow, or umbilical cord blood) were used. [Oncotarget] Full Article

Chaotic Time Series Prediction for Prenatal Exposure to Polychlorinated Biphenyls in Umbilical Cord Blood Using the Least Squares SEATR Model
Investigators studied prenatal exposure to polychlorinated biphenyls by chaotic time series prediction using the least squares self-exciting threshold autoregressive (SEATR) model in umbilical cord blood in an electronic waste contaminated area. [Sci Rep] Full Article

Equine Mesenchymal Stromal Cells (MSC) from Different Sources Efficiently Differentiate into Hepatocyte Like Cells (HLC)
Researchers differentiated equine umbilical cord blood (UCB)-derived MSC into HLC and found that these cells exhibited a distinct polygonal morphology, stored glycogen as visualized by periodic acid Schiff’s reagent staining, and were positive for albumin and other hepatocyte-specific genes. They demonstrated that UCB-HLC could be revived following cryopreservation and retained their phenotype for at least ten days. [Tissue Eng Part C Methods] Abstract

The Differentiation of Amniotic Fluid Stem Cells into Sweat Gland-Like Cells Is Enhanced by the Presence of Shh in the Conditioned Medium
Researchers induced CD117+ human amniotic fluid stem cells to differentiate into sweat gland-like cells based on use of conditioned medium from the human sweat gland cells. [Exp Dermatol] Abstract

Stiffness-Controlled Three-Dimensional Collagen Scaffolds for Differentiation of Human Wharton’s Jelly Mesenchymal Stem Cells into Cardiac Progenitor Cells
Investigators developed stiffness-controlled collagen scaffolds to allow proliferation and differentiation of mesenchymal stem cell into cardiac progenitor cells. Transforming growth factor β2, was used to induce stem cell differentiation into cardiac lineage cells. [J Biomed Mater Res A] Abstract

Immunoregulatory Function of Neonatal Nucleated Red Blood Cells in Humans
Investigators found that human cord blood nucleated red blood cells have a regulatory function in the innate immune reaction. These cells suppressed the production of inflammatory cytokines including TNF-α and IL-1β from monocytes in response to lipopolysaccharide. [Immunobiology] Abstract

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Emerging Strategies for the Treatment of Older Patients with Acute Myeloid Leukemia
The authors discuss current treatment paradigms for older patients with acute myeloid leukemia including the challenges faced when determining which patients are eligible for intensive chemotherapy. They then highlight new treatments in development that may benefit this patient group. Cytotoxic agents, hypomethylating agents, molecularly targeted agents, and cell cycle kinase inhibitors are discussed, with a focus on novel agents that have achieved an advanced stage of development. [Ann Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
Merck Receives Breakthrough Therapy Designation from U.S. Food and Drug Administration for KEYTRUDA® (Pembrolizumab) in Classical Hodgkin Lymphoma (cHL)
Merck announced that the U.S. Food and Drug Administration has granted breakthrough therapy designation to KEYTRUDA®, the company’s anti-PD-1 therapy, for the treatment of patients with relapsed or refractory cHL. [Merck] Press Release

AstraZeneca Launches Integrated Genomics Approach to Transform Drug Discovery and Development
AstraZeneca and its global biologics research and development arm, MedImmune, announced an integrated genomics initiative to transform drug discovery and development across its entire research and development pipeline. [AstraZeneca] Press Release

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National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 4th Annual Conference of the German Stem Cell Network (GSCN)
September 12-14, 2016
Hanover, Germany

Visit our events page to see a complete list of events in the cord blood community.
NEW Postdoctoral Research Associate – TAM-Family Kinases in Leukemogenesis (Emory University)

Postdoctoral Research Fellow – Cancer Stem Cell Biology (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania)

Principal Investigator – Stem Cell Biology and Regeneration Medicine (Guangzhou Women and Children’s Medical Center)

Engineering Project Lead (Cytonome)

Postdoctoral Scientist – Hematological Malignancies (Max Delbruck Center for Molecular Medicine in the Helmholtz Association)

Postdoctoral Research Associate – Pediatric Acute Lymphoblastic Leukemia (University of Pittsburgh)

Postdoctoral Research Associate – Blood Stem Cell Microenvironment (University of Illinois)

Associate Scientist – Hematopoietic Stem Cell Biology (Editas Medicine)

Research Associate – Hematopoietic Stem Cell Biology (Editas Medicine)

Postdoctoral Fellow – Hematology/Oncology (Boston Children’s Hospital)

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