Volume 8.17 | May 5

Cord Blood News 8.17 May 5, 2016
Cord Blood News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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Human Umbilical Cord Matrix-Derived Stem Cells Expressing Interferon-β Gene Inhibit Breast Cancer Cells via Apoptosis
Researchers investigated the anti-tumor effect of interferon-β gene-transfected human umbilical cord mesenchymal stem cells on breast cancer cells with emphasis on triple negative breast carcinoma. [Oncotarget] Full Article
Learn more about MegaCult™-C collagen-based medium for colony-forming unit - megakaryocyte (CFU-Mk) assays of human or mouse hematopoietic progenitor cells.
PUBLICATIONS (Ranked by impact factor of the journal)
Generation of Genetically Engineered Precursor T Cells from Human Umbilical Cord Blood Using an Optimized Alpharetroviral Vector Platform
Cord blood-derived CD34+ cells were transduced and differentiated into precursor T cells in vitro. Two promoters, elongation-factor-1-short-form, and a myeloproliferative-sarcoma-virus variant in combination with two commonly used envelopes were comparatively assessed choosing green fluorescent protein or a third generation chimeric antigen receptor against CD123 as gene of interest. [Mol Ther] Abstract

Plet1 Is an Epigenetically Regulated Cell Surface Protein that Provides Essential Cues to Direct Trophoblast Stem Cell Differentiation
Investigators assessed placenta expressed transcript 1 (Plet1), for its function in establishing trophoblast lineage identity and modulating trophoblast differentiation. [Sci Rep] Full Article

Proteome Analysis of Human Amniotic Mesenchymal Stem Cells (hA-MSCs) Reveals Impaired Antioxidant Ability, Cytoskeleton and Metabolic Functionality in Maternal Obesity
Researchers studied the proteome of 12 obese (Ob-) and six non-obese (Co-) hA-MSCs obtained from women at delivery by cesarean section. The proteome, investigated by two-dimensional fluorescence difference gel electrophoresis/mass spectrometry, revealed 62 differently expressed proteins in Ob- vs Co- hA-MSCs, nine of which were confirmed by western blotting. [Sci Rep] Full Article

Cellular Dynamics of Mouse Trophoblast Stem Cells: Identification of a Persistent Stem Cell Type
Scientists characterized trophoblast stem cell (TSC) colony types by using methods based on cell biology and biochemistry for a better understanding of how TSCs are maintained over multiple passages. [Biol Reprod] Abstract | Full Article

Levels of Adipokines in Amniotic Fluid and Cord Blood Collected from Dichorionic-Diamniotic Twins Discordant for Fetal Growth
Researchers compared the concentrations of adipokines in amniotic fluid and cord blood collected from discordant dichorionic-diamniotic twin fetuses. [PLoS One] Full Article

An Alternative to Dextran for the Thawing of Cord Blood Units
Preparation of umbilical cord blood units for infusion requires a step of dilution or washing to reduce the toxicity of the dimethyl sulfoxide present in the freezing solution. However, the worldwide shortage of clinical-grade dextran 40, the most widely used cord blood dilution or washing solution, prompted the authors to search for an alternative solution. [Transfusion] Abstract

Early Phase Mixed Chimerism in Bone Marrow Does Not Affect Long-Term Outcomes of Myeloablative Single-Unit Cord Blood Transplantation for Adult Patients with Hematological Malignancies
Investigators retrospectively analyzed 150 adult patients who received myeloablative single-unit cord blood transplantation (CBT) for hematological malignancies. They showed that early phase mixed chimerism did not have a significant impact on long-term outcomes after myeloablative single-unit CBT for hematological malignancies. [Leuk Lymphoma] Abstract

Learn more about our standardized tools for cord blood banking
Comparison of In Vitro-Cultivation of Human Mesenchymal Stroma/Stem Cells Derived from Bone Marrow and Umbilical Cord
The authors discuss and summarize certain experimental conditions for mesenchymal stroma/stem cells (MSCs) in vitro culture focusing on adult bone marrow-derived and neonatal umbilical cord-derived MSCs in order to enhance the understanding for MSC tissue sources and to stratify different procedures. [J Tissue Eng Regen Med] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.
Genentech Highlights Personalized Medicines and Cancer Immunotherapies
Genentech announced new results from 19 approved and investigational medicines will be presented. More than 200 abstracts have been accepted across eight cancer types, including four “late breakers” and nearly 30 oral presentations. [Press release from Genentech, Inc. discussing research to be presented at the American Society of Clinical Oncology (ASCO) 2016 Annual Meeting, Chicago] Press Release

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Astellas and the CNTRP Continue Partnership and Commitment to Canadian Research Innovation
Astellas Pharma Canada, Inc. and the Canadian National Transplant Research Program (CNTRP) announced the recipients of the second CNTRP Astellas Research Innovation Grant Competition. The grant recipients each received $25,000 to support peer-reviewed pilot research projects that align with a key strategic research priority for the CNTRP in the area of personalized medicine approaches in transplantation to improve health outcomes. [Astellas Pharma Canada, Inc.] Press Release

Janssen’s IMBRUVICA® Receives Positive CHMP Opinion for Expanded Use in Previously Untreated Chronic Lymphocytic Leukemia Patients
Janssen-Cilag International NV announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a Positive Opinion, recommending broadening the existing marketing authorization for ibrutinib as a single agent for the treatment of adult patients with previously untreated chronic lymphocytic leukemia. [Janssen-Cilag International NV] Press Release
Nine Years of Censorship
Canadian scientists are now allowed to speak out about their work — and the government policy that had restricted communications. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Nordic Life Science Days 2016
September 14-15, 2016
Stockholm, Sweden

Visit our events page to see a complete list of events in the cord blood community.
NEW Postdoctoral Studies – Computational Transcriptomics and Epigenetics in Acute Myeloid Leukemia (Karolinska Institutet)

Postdoctoral Research Associate – TAM-Family Kinases in Leukemogenesis (Emory University)

Postdoctoral Research Fellow – Cancer Stem Cell Biology (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania)

Principal Investigator – Stem Cell Biology and Regeneration Medicine (Guangzhou Women and Children’s Medical Center)

Engineering Project Lead (Cytonome)

Postdoctoral Research Associate – Pediatric Acute Lymphoblastic Leukemia (University of Pittsburgh)

Postdoctoral Research Associate – Blood Stem Cell Microenvironment (University of Illinois)

Associate Scientist – Hematopoietic Stem Cell Biology (Editas Medicine)

Research Associate – Hematopoietic Stem Cell Biology (Editas Medicine)

Postdoctoral Fellow – Hematology/Oncology (Boston Children’s Hospital)

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