Volume 8.18 | May 12

Cord Blood News 8.18 May 12, 2016
Cord Blood News
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Olig2 Is Expressed Late in Human Eosinophil Development and Controls Siglec-8 Expression
When cord blood CD34+ hematopoietic stem cells differentiated toward eosinophils during a 24 day culture period, oligodendrocyte transcription factor 2 protein was expressed in cord blood eosinophils on day 24, a time when cord blood eosinophils are considered fully differentiated, whereas it was not detectable on day 18 or at earlier time points. [J Leukoc Biol] Abstract | Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Cord Blood-Derived Endothelial Colony-Forming Cell Function Is Disrupted in Congenital Diaphragmatic Hernia
Investigators hypothesized that the function of endothelial colony-forming cells (ECFCs), a type of endothelial progenitor cell, is impaired in congenital diaphragmatic hernia (CDH). Cord blood (CB) was collected from full-term CDH patients and healthy controls. They assessed CB progenitor cell populations as well as plasma vascular endothelial growth factor and stromal cell-derived factor 1α levels. [Am J Physiol Lung Cell Mol Physiol] Abstract

The Migration and Differentiation of hUC-MSCs(CXCR4/GFP) Encapsulated in BDNF/Chitosan Scaffolds for Brain Tissue Engineering
Given the low expression level of chemokine (C-X-C motif) receptor (CXCR)4 on the human umbilical cord mesenchymal stem cells (hUC-MSC) membrane, lentiviral vectors were used to generate hUC-MSCs stably expressing CXCR4 fused to green fluorescent protein (GFP). [Biomed Mater] Full Article

Stirred Tank Bioreactor Culture Combined with Serum-/Xenogeneic-Free Culture Medium Enables an Efficient Expansion of Umbilical Cord-Derived Mesenchymal Stem/Stromal Cells
Researchers established a spinner flask culture system combining gelatin-based Cultispher®S microcarriers and xeno-free culture medium for the expansion of umbilical cord matrix-derived mesenchymal stem/stromal cells. [Biotechnol J] Abstract

Hydroquinone Induces DNA Hypomethylation-Independent Overexpression of Retroelements in Human Leukemia and Hematopoietic Stem Cells
The authors found a clear tendency towards increased retrotransposon expression in response to hydroquinone exposure, more pronounced in the case of LINE-1 and HERV. [Biochem Biophys Res Commun] Abstract

The Transplantation of Akt-Overexpressing Amniotic Fluid-Derived Mesenchymal Stem Cells Protects the Heart against Ischemia-Reperfusion Injury in Rabbits
The Akt gene was overexpressed in amniotic fluid-derived mesenchymal stem cells (AFMSCs) using lentiviral transduction, and Akt‑AFMSCs were transplanted into the ischemic myocardium of rabbits prior to reperfusion. Any protective effects resulting from this procedure were subsequently sought after three weeks. [Mol Med Rep] Abstract | Download Full Article

Therapeutic Effects of Wharton Jelly-Derived Mesenchymal Stem Cells on Rat Abortion Models
Researchers investigated the therapeutic effects and mechanism of Wharton jelly-derived mesenchymal stem cells in a spontaneous-abortion rat model. [J Obstet Gynaecol Res] Abstract

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Genetic and Epigenetic Heterogeneity in Acute Myeloid Leukemia
The authors review recent advances in genetic and epigenetic heterogeneity and clonal dynamics in acute myeloid leukemia and their relevance to biology, clinical outcomes and therapeutic implications. [Curr Opin Genet Dev] Abstract

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Yissum and BioTheryX Sign Licensing Agreement for the Development of Next-Generation Protein Degradation and Immunomodulatory Treatment for Hematological Cancers
Yissum Research Development Company of the Hebrew University of Jerusalem announced that it had signed an exclusive world-wide licensing and research agreement with BioTheryX, Inc., developer of novel protein degradation and immunomodulatory drugs for cancer and immune dysfunction, for the development and commercialization of drug candidates representing first-in-class therapy for hematologic and solid malignancies. [Yissum Research Development Company of the Hebrew University of Jerusalem] Press Release

Scripps Florida Awarded $2.5 Million to Advance Development of RNA-Based Therapeutics
Scientists from the Florida campus of The Scripps Research Institute have been awarded a $2.5 million grant from the National Institute of General Medical Sciences of the National Institutes of Health to design precision drug candidates that target disease-associated RNAs. [The Scripps Research Institute] Press Release

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Therapeutic Goods Administration (Australia)
NEW Nordic Life Science Days 2016
September 14-15, 2016
Stockholm, Sweden

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NEW Postdoctoral Studies – Computational Transcriptomics and Epigenomics in Acute Myeloid Leukemia (Karolinska Institutet)

NEW Postdoctoral Positions – Stem Cell Biology and Regenerative Medicine (University of Southern California)

Postdoctoral Research Associate – TAM-Family Kinases in Leukemogenesis (Emory University)

Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania)

Principal Investigator – Stem Cell Biology and Regeneration Medicine (Guangzhou Women and Children’s Medical Center)

Postdoctoral Research Associate – Pediatric Acute Lymphoblastic Leukemia (University of Pittsburgh)

Associate Scientist – Hematopoietic Stem Cell Biology (Editas Medicine)

Research Associate – Hematopoietic Stem Cell Biology (Editas Medicine)

Postdoctoral Fellow – Hematology/Oncology (Boston Children’s Hospital)

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